ChloroquineV1, France, Analysis, bibRecord, 000022

Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib

Identifieur interne : 000022 ( France/Analysis ); précédent : 000021; suivant : 000023

Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib

Auteurs : Laure Ricard [France] ; Vincent Jachiet [France] ; Florent Malard [France] ; Yishan Ye ; Nicolas Stocker ; Sébastien Rivière [France] ; Patricia Senet [France] ; Jean-Benoit Monfort [États-Unis] ; Olivier Fain [France] ; Mohamad Mohty [France] ; Béatrice Gaugler [France] ; Arsène Mékinian [France]

Source :

Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2019.

RBID : Hal:hal-02178935

Abstract

Approximately 1 to 3% of women have recurrent early miscarriages, defined as ≥3 pregnancy losses before 14 weeks of gestation. The immune deregulation and tolerance rupture could be the origin of these miscarriages in at least 30% of these women. Chronic intervillositis of unknown etiology (CIUE) is a rare placental lesion characterized by intrauterine deaths, growth restriction and high recurrence rate. In cases with recurrent obstetrical adverse events and intrauterine deaths, we previously reported the benefit of hydroxychloroquine combination to prednisone. Even few data raised the potential value of TNF antagonists in early recurrent miscarriages, these cases show its potential value in the setting of recurrent refractory chronic intervillositis and unexplained miscarriages.

Url:

https://hal.sorbonne-universite.fr/hal-02178935

DOI: 10.1136/annrheumdis-2018-214382

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000052
to stream Hal, to step Curation: 000052
to stream Hal, to step Checkpoint: 000019
to stream Main, to step Merge: 000250
to stream Main, to step Curation: 000250
to stream Main, to step Exploration: 000250
to stream France, to step Extraction: 000022

Links to Exploration step

Hal:hal-02178935

Le document en format XML

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          </desc>
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</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Ye, Yishan" sort="Ye, Yishan" uniqKey="Ye Y" first="Yishan" last="Ye">Yishan Ye</name>
</author>
<author><name sortKey="Stocker, Nicolas" sort="Stocker, Nicolas" uniqKey="Stocker N" first="Nicolas" last="Stocker">Nicolas Stocker</name>
</author>
<author><name sortKey="Riviere, Sebastien" sort="Riviere, Sebastien" uniqKey="Riviere S" first="Sébastien" last="Rivière">Sébastien Rivière</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-246522" status="VALID">          <orgName>Service de rhumatologie, inflammation-immunopathologie- biothérapie [CHU Saint-Antoine]</orgName>
          <orgName type="acronym">DHU i2B </orgName>
          <desc>            <address>              <addrLine>184, rue du Faubourg Saint-Antoine, F-75012 Paris</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
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        <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID">          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-454982" type="direct"><org type="institution" xml:id="struct-454982" status="VALID">          <orgName>CHU Saint-Antoine [APHP]</orgName>
          <desc>            <address>              <addrLine>184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-saint-antoine-1</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Senet, Patricia" sort="Senet, Patricia" uniqKey="Senet P" first="Patricia" last="Senet">Patricia Senet</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-223222" status="VALID">          <orgName>Service de Dermatologie [CHU Tenon]</orgName>
          <desc>            <address>              <addrLine>4 Rue de la Chine 75020 Paris</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300068" type="direct"></relation>
            <relation active="#struct-328304" type="direct"></relation>
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        <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID">          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
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</tutelle>
<tutelle active="#struct-328304" type="direct"><org type="institution" xml:id="struct-328304" status="VALID">          <orgName>CHU Tenon [APHP]</orgName>
          <desc>            <address>              <addrLine>4 Rue de la Chine, 75020 Paris</addrLine>
              <country key="FR"></country>
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            <ref type="url">http://www.aphp.fr/contenu/hopital-tenon-1</ref>
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</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Monfort, Jean Benoit" sort="Monfort, Jean Benoit" uniqKey="Monfort J" first="Jean-Benoit" last="Monfort">Jean-Benoit Monfort</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-66086" status="VALID">          <orgName>Department of Civil and Environmental Engineering [Durham]</orgName>
          <orgName type="acronym">CEE</orgName>
          <desc>            <address>              <addrLine>Room 121 Hudson Hall, Box 90287, Durham, NC 27708-0287</addrLine>
              <country key="US"></country>
            </address>
            <ref type="url">http://www.cee.duke.edu/</ref>
          </desc>
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          <orgName>Duke University [Durham]</orgName>
          <desc>            <address>              <addrLine>Durham, NC 27708</addrLine>
              <country key="US"></country>
            </address>
            <ref type="url">http://www.duke.edu/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Fain, Olivier" sort="Fain, Olivier" uniqKey="Fain O" first="Olivier" last="Fain">Olivier Fain</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-493499" status="VALID">          <orgName>Service de Médecine Interne [CHU Saint-Antoine]</orgName>
          <desc>            <address>              <country key="FR"></country>
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          <orgName type="acronym">APHP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-454982" type="direct"><org type="institution" xml:id="struct-454982" status="VALID">          <orgName>CHU Saint-Antoine [APHP]</orgName>
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              <country key="FR"></country>
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</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Mohty, Mohamad" sort="Mohty, Mohamad" uniqKey="Mohty M" first="Mohamad" last="Mohty">Mohamad Mohty</name>
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          <orgName>Centre de Recherche Saint-Antoine</orgName>
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          <desc>            <address>              <country key="FR"></country>
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          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
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            <ref type="url">http://www.inserm.fr</ref>
          </desc>
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</tutelle>
<tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="OLD">          <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
          <orgName type="acronym">UPMC</orgName>
          <date type="end">2017-12-31</date>
          <desc>            <address>              <addrLine>4 place Jussieu - 75005 Paris</addrLine>
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          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Gaugler, Beatrice" sort="Gaugler, Beatrice" uniqKey="Gaugler B" first="Béatrice" last="Gaugler">Béatrice Gaugler</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182215" status="VALID">          <idno type="IdRef">166218421</idno>
          <orgName>Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)</orgName>
          <orgName type="acronym">HOTE GREFFON</orgName>
          <desc>            <address>              <addrLine>I.B.C.T. Bâtiment Inserm 240 Route de Dole/Rue F. Dolto 25000 Besançon</addrLine>
              <country key="FR"></country>
            </address>
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          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-439502" type="direct"><org type="institution" xml:id="struct-439502" status="VALID">          <orgName>Etablissement français du sang [Bourgogne-France-Comté] </orgName>
          <orgName type="acronym">EFS [Bourgogne-France-Comté]</orgName>
          <desc>            <address>              <addrLine>1 Boulevard Fleming 25020 Besançon cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.dondusang.net</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-458810" type="direct"><org type="institution" xml:id="struct-458810" status="VALID">          <idno type="IdRef">026403188</idno>
          <idno type="ISNI">0000 0001 2188 3779 </idno>
          <orgName>Université de Franche-Comté</orgName>
          <orgName type="acronym">UFC</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-fcomte.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city" wicri:auto="siege">Besançon</settlement>
<region type="region" nuts="2">Franche-Comté</region>
</placeName>
<orgName type="university">Université de Franche-Comté</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Bourgogne Franche-Comté</orgName>
</affiliation>
</author>
<author><name sortKey="Mekinian, Arsene" sort="Mekinian, Arsene" uniqKey="Mekinian A" first="Arsène" last="Mékinian">Arsène Mékinian</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-413221" status="VALID">          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1136/annrheumdis-2018-214382</idno>
<series><title level="j">Annals of the Rheumatic Diseases</title>
<idno type="ISSN">0003-4967</idno>
<imprint><date type="datePub">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>Approximately 1 to 3% of women have recurrent early miscarriages, defined as ≥3 pregnancy losses before 14 weeks of gestation. The immune deregulation and tolerance rupture could be the origin of these miscarriages in at least 30% of these women. Chronic intervillositis of unknown etiology (CIUE) is a rare placental lesion characterized by intrauterine deaths, growth restriction and high recurrence rate. In cases with recurrent obstetrical adverse events and intrauterine deaths, we previously reported the benefit of hydroxychloroquine combination to prednisone. Even few data raised the potential value of TNF antagonists in early recurrent miscarriages, these cases show its potential value in the setting of recurrent refractory chronic intervillositis and unexplained miscarriages.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>États-Unis</li>
</country>
<region><li>Franche-Comté</li>
</region>
<settlement><li>Besançon</li>
</settlement>
<orgName><li>Université de Bourgogne Franche-Comté</li>
<li>Université de Franche-Comté</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Stocker, Nicolas" sort="Stocker, Nicolas" uniqKey="Stocker N" first="Nicolas" last="Stocker">Nicolas Stocker</name>
<name sortKey="Ye, Yishan" sort="Ye, Yishan" uniqKey="Ye Y" first="Yishan" last="Ye">Yishan Ye</name>
</noCountry>
<country name="France"><noRegion><name sortKey="Ricard, Laure" sort="Ricard, Laure" uniqKey="Ricard L" first="Laure" last="Ricard">Laure Ricard</name>
</noRegion>
<name sortKey="Fain, Olivier" sort="Fain, Olivier" uniqKey="Fain O" first="Olivier" last="Fain">Olivier Fain</name>
<name sortKey="Gaugler, Beatrice" sort="Gaugler, Beatrice" uniqKey="Gaugler B" first="Béatrice" last="Gaugler">Béatrice Gaugler</name>
<name sortKey="Jachiet, Vincent" sort="Jachiet, Vincent" uniqKey="Jachiet V" first="Vincent" last="Jachiet">Vincent Jachiet</name>
<name sortKey="Malard, Florent" sort="Malard, Florent" uniqKey="Malard F" first="Florent" last="Malard">Florent Malard</name>
<name sortKey="Mekinian, Arsene" sort="Mekinian, Arsene" uniqKey="Mekinian A" first="Arsène" last="Mékinian">Arsène Mékinian</name>
<name sortKey="Mohty, Mohamad" sort="Mohty, Mohamad" uniqKey="Mohty M" first="Mohamad" last="Mohty">Mohamad Mohty</name>
<name sortKey="Riviere, Sebastien" sort="Riviere, Sebastien" uniqKey="Riviere S" first="Sébastien" last="Rivière">Sébastien Rivière</name>
<name sortKey="Senet, Patricia" sort="Senet, Patricia" uniqKey="Senet P" first="Patricia" last="Senet">Patricia Senet</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Monfort, Jean Benoit" sort="Monfort, Jean Benoit" uniqKey="Monfort J" first="Jean-Benoit" last="Monfort">Jean-Benoit Monfort</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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   |texte=   Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib
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Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib

Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib

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